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Article

Intracellular quality control of mitochondrial DNA: evidence and limitations

2 Dec 2019

Abstract excerpt

Eukaryotic cells can harbour mitochondria with markedly different transmembrane potentials. Intracellular mitochondrial quality-control mechanisms (e.g. mitophagy) rely on this intracellular variation to distinguish functional and damaged (depolarized) mitochondria. Given that intracellular mitochondrial DNA (mtDNA) genetic variation can induce mitochondrial heterogeneity, mitophagy could remove deleterious mtDNA...

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Identifiers

PMID: 31787047
DOI: 10.1098/rstb.2019.0176

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