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Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast.

Aging cell - 1 Oct 2011

McFaline-Figueroa José Ricardo, Vevea Jason, Swayne Theresa C, Zhou Chun, Liu Christopher, Leung Galen, Boldogh Istvan R, Pon Liza A

Abstract excerpt

Fluorescence loss in photobleaching experiments and analysis of mitochondrial function using superoxide and redox potential biosensors revealed that mitochondria within individual yeast cells are physically and functionally distinct. Mitochondria that are retained in mother cells during yeast cell division have a significantly more oxidizing redox potential and higher superoxide levels compared to mitochondria in...

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Identifiers

PMID: 21726403
DOI: 10.1111/j.1474-9726.2011.00731.x
PMCID: PMC3173513

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