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Article

Local mitochondrial physiology defined by mtDNA quality guides purifying selection.

PLoS genetics - 1 Jan 2026

Thoma Felix, Hagen Johannes, Rathberger Romina, Padovani Francesco, Hörl David, Schmoller Kurt M, Osman Christof

Abstract excerpt

The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain and ATP synthase. Mutations in these genes impair oxidative phosphorylation, compromise mitochondrial ATP production and cellular energy supply, and can cause mitochondrial diseases. These consequences highlight the importance of mtDNA quality control (mtDNA-QC), the process by which cells selectively maintain intact mtDNA...

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Identifiers

PMID: 41512010
DOI: 10.1371/journal.pgen.1011836
PMCID: PMC12810922

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