Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell analysis reveals context-dependent, cell-level selection of mtDNA.

Nature - 1 May 2024

Kotrys Anna V, Durham Timothy J, Guo Xiaoyan A, Vantaku Venkata R, Parangi Sareh, Mootha Vamsi K

Abstract excerpt

Heteroplasmy occurs when wild-type and mutant mitochondrial DNA (mtDNA) molecules co-exist in single cells1. Heteroplasmy levels change dynamically in development, disease and ageing2,3, but it is unclear whether these shifts are caused by selection or drift, and whether they occur at the level of cells or intracellularly. Here we investigate heteroplasmy dynamics in dividing cells by combining precise mtDNA base...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Lineage
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Editing

Share to Genetic Fitness

Share to Heteroplasmy

Share to Mitochondria

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 38658765
DOI: 10.1038/s41586-024-07332-0
PMCID: PMC11078733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell analysis reveals context-dependent, cell-level selection of mtDNA.PMID 38658765Read ↗

Robustness and reliability of single-cell regulatory multi-omics with deep mitochondrial mutation profilingSemantic proximity Read ↗

Large-scale single-cell mapping of concealed mitochondrial ageingSemantic proximity Read ↗

High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life.Semantic proximity Read ↗

Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics.Semantic proximity Read ↗

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read ↗

Single-cell multi-omics resolved analysis of mitochondrial genome-wide mutational burden, constraint, and mosaicismSemantic proximity Read ↗

Exploring Heteroplasmic Variants in mtDNA: Insights from Single-Cell TranscriptomicsSemantic proximity Read ↗

Stable heteroplasmy at the single cell level is facilitated by inter-cellular exchange of mtDNASemantic proximity Read ↗

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling.Semantic proximity Read ↗

Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA.Semantic proximity Read ↗

Population Diversity at the Single-Cell Level.Semantic proximity Read ↗

Exploring Heteroplasmic Variants in mtDNA: Insights from Single-Cell Transcriptomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.