Article

A Simulation Analysis and Screening of Deleterious Non-Synonymous Single Nucleotide Polymorphisms (SNPs) in Human CDKN1A Gene

2017-12-29

Abstract excerpt

CDKN1A also known as p21 CIP1 /p21 WAF1 , a cyclin dependent kinase 1, interacts with proliferating cell nuclear antigen (PCNA) resulting in cell cycle inhibition in human. Non-synonymous single nucleotide polymorphisms (nsSNPs), which reside in the coding region of a gene, might distort the normal function of the corresponding protein. In silico analysis in this study followed many different algorithms. Follow...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9336f363-498b-56c3-a773-4a4b084e5646
DOI: 10.1101/240820

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Simulation Analysis and Screening of Deleterious Non-Synonymous Single Nucleotide Polymorphisms (SNPs) in Human CDKN1A GeneDOI 10.1101/240820Read

Computational screening and analysis of deleterious nsSNPs in human p14ARF (CDKN2A gene) protein using molecular dynamic simulation approach.Semantic proximity Read

Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.Semantic proximity Read

In silico analysis of structural and functional consequences in p16INK4A by deleterious nsSNPs associated CDKN2A gene in malignant melanoma.Semantic proximity Read

Computational analysis of Cyclin D1 gene SNPs and association with breast cancer.Semantic proximity Read

Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies.Semantic proximity Read

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach.Semantic proximity Read

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene.Semantic proximity Read

Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach.Semantic proximity Read

In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene.Semantic proximity Read

Association of CCND1 Gene c.870G>A Polymorphism with Breast Cancer Risk: A Case-ControlStudy and a Meta-Analysis.Semantic proximity Read

In-silico screening of cancer associated mutation on PLK1 protein and its structural consequences.Semantic proximity Read

Predicting the impact of single-nucleotide polymorphisms in CDK2-flavopiridol complex by molecular dynamics analysis.Semantic proximity Read