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Computational analysis of Cyclin D1 gene SNPs and association with breast cancer.

Bioscience reports - 29 Jan 2021

Aftab Ayesha, Khan Ranjha, Shah Wasim, Azhar Muhammad, Unar Ahsanullah, Jafar Hussain Hafiz Muhammad, Waqas Ahmed

Abstract excerpt

CCND1 encodes for Cyclin D1 protein and single-nucleotide polymorphisms (SNPs) can modulate its activity. In the present study, the impact of CCND1 SNPs on structure and/or function of Cyclin D1 protein using in silico tools was investigated. Our analysis revealed only one splice site SNP (c.1988+5G<A) can effect CCND1 function. Subsequently, 78 out of 169 missense variants were predicted as pathogenic by...

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Identifiers

PMID: 33438725
DOI: 10.1042/BSR20202269
PMCID: PMC7846961

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