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Article

Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.

PloS one - 1 Jan 2021

Islam Rahatul, Rahaman Mashiur, Hoque Hammadul, Hasan Nazmul, Prodhan Shamsul H, Ruhama Asfia, Jewel Nurnabi Azad

Abstract excerpt

Cycline-dependent kinase 4 (CDK4), an enzyme of the cycline dependent or Ser/Thr protein kinase family, plays a role in cell cycle progression (G1 phase) by phosphorylating a tumor suppressor protein called pRB. Alteration of this enzyme due to missense mutation/ nonsynonymous single nucleotide polymorphisms (nsSNPs) are responsible for various types of cancer progression, e.g. melanoma, lung cancer, and breast...

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Identifiers

PMID: 34735543
DOI: 10.1371/journal.pone.0259691
PMCID: PMC8568134

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