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Article

In-silico screening of cancer associated mutation on PLK1 protein and its structural consequences.

Journal of molecular modeling - 1 Dec 2013

Kamaraj Balu, Rajendran Vidya, Sethumadhavan Rao, Purohit Rituraj

Abstract excerpt

The Polo-like kinases (Plks) are a conserved subfamily of serine-threonine protein kinases that have significant roles in cell proliferation. The serine/threonine protein kinases or polo-like kinase 1 (PLK1) exist in centrosome during interphase and is an important regulatory enzyme in cell cycle progression during M phase. Mutations in mammalian PLK1 were found to be over expressed in various human cancers and...

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Source

Identifiers

PMID: 24271645
DOI: 10.1007/s00894-013-2044-0

Genes

PLK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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