Article

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease

2025-05-12

Abstract excerpt

<h4>ABSTRACT</h4> The role of cell-specific ANGPTL4 is not well known in the context of ECs, specifically in pathological angiogenesis and its relation to diabetic kidney disease. Here, we demonstrate that endothelial ANGPTL4 is required to induce a metabolic phenotype that favors mesenchymal activation in ECs and tubules in diabetic conditions. Diabetes accelerates mesenchymal activation and fibrogenesis in cont...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 487609b2-94f2-5dcf-b4b9-ba6e56642bd8
DOI: 10.1101/2025.05.08.652142

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney diseaseDOI 10.1101/2025.05.08.652142Read

Single-cell insights into maladaptive endothelial plasticity and therapeutic targets in diabetic vascular complications.Semantic proximity Read

Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney diseaseSemantic proximity Read

Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneysSemantic proximity Read

3D Endothelium-on-a-Chip Reveals Cx43/LDHA Axis as a Driver of Endothelial Barrier Dysfunction in Diabetic Kidney DiseaseSemantic proximity Read

Kidney single-cell transcriptomes uncover SGLT2i-induced metabolic reprogramming via restoring glycolysis and fatty acid oxidationSemantic proximity Read

Identifying Key Genes for Diabetic Kidney Disease by Bioinformatics AnalysisSemantic proximity Read

Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysisSemantic proximity Read

Glomerular endothelial cell heterogeneity in Alport syndromeSemantic proximity Read

Endothelial Kallikrein-Related Peptidase 8 Promotes Diabetic Nephropathy through a LIFR dependent mechanismSemantic proximity Read

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease SusceptibilitySemantic proximity Read

Multi‐organ single‐cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulationSemantic proximity Read

Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathologySemantic proximity Read