Article

Clinically approved HIF‑PHIs modulate redox metabolism, cell growth, and angiogenesis independent of HIF‑1α/HIF‑2α

2026-05-08

Abstract excerpt

<title>Abstract</title> <p>HIF-prolyl hydroxylase inhibitors are used to treat anemia in chronic kidney disease. These drugs stabilize hypoxia-inducible factors HIF-1α and HIF-2α, which activate erythropoiesis and iron metabolism pathways. Clinically approved HIF-PHIs including roxadustat and molidustat exhibit distinct molecular structures and selectivity profiles, yet their HIF-independent effects remain poorly...

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Literature Corpus work: 99ced1db-e9dd-5340-b9af-4538c40e22b9
DOI: 10.21203/rs.3.rs-8582402/v2

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