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Article

Genetic-based patient stratification in Alzheimer's disease.

Scientific reports - 30 Apr 2024

Hernández-Lorenzo Laura, García-Gutiérrez Fernando, Solbas-Casajús Ana, Corrochano Silvia, Matías-Guiu Jordi A, Ayala Jose L

Abstract excerpt

Alzheimer's disease (AD) shows a high pathological and symptomatological heterogeneity. To study this heterogeneity, we have developed a patient stratification technique based on one of the most significant risk factors for the development of AD: genetics. We addressed this challenge by including network biology concepts, mapping genetic variants data into a brain-specific protein-protein interaction (PPI)...

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PMID: 38693203
DOI: 10.1038/s41598-024-60707-1
PMCID: PMC11063050

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