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Integrating Human Brain Proteomic Data with Genome-Wide Association Study Findings Identifies Novel Brain Proteins in Substance Use Traits

2022-02-04

Abstract excerpt

<h4>Background: </h4> Despite the growing number of genetic risk loci identified for substance use traits (SUTs), the impact of these loci on protein abundance and their potential as therapeutic targets are unknown. <h4>Methods:</h4> To address this, we performed a proteome-wide association study (PWAS) by integrating human brain proteomes from discovery (Banner; N = 152) and validation (ROSMAP; N = 376) datasets...

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Literature Corpus work: 92ddc620-e67e-5c03-9cd9-311719d12137
DOI: 10.1101/2022.02.02.22270270

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