Article
Transcriptome-wide association study by different approaches reveals candidate causal genes for cannabis use disorder.
Gene - 30 Jan 2023
Gao Jiayang, Guo Xin, Yan Chunxia, Gong Xiaojuan, Ma Pan, Gu Shanzhi, Zhang Bao
Abstract excerpt
Cannabis is one of the most commonly used psychoactive substances, which could induce moderate-severe cannabis use disorders (CUD). Here, a tissue-specific transcriptome-wide association study (TWAS) of CUD was performed by FUSION and S-PrediXcan, utilizing a genome-wide association study (GWAS) dataset of CUD (including 43,380 cases and 141,385 controls of European ancestry) and gene expression reference data...
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