Article
Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci.
Drug and alcohol dependence - 1 Jan 2020
Marees Andries T, Gamazon Eric R, Gerring Zachary, Vorspan Florence, Fingal Josh, van den Brink Wim, Smit Dirk J A, Verweij Karin J H, Kranzler Henry R, Sherva Richard, Farrer Lindsay, Gelernter Joel, Derks Eske M
Abstract excerpt
BACKGROUND: Little is known about the functional mechanisms through which genetic loci associated with substance use traits ascertain their effect. This study aims to identify and functionally annotate loci associated with substance use traits based on their role in genetic regulation of gene expression. METHODS: We evaluated expression Quantitative Trait Loci (eQTLs) from 13 brain regions and whole blood of the...
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