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Article

Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2022

Toikumo Sylvanus, Xu Heng, Gelernter Joel, Kember Rachel L, Kranzler Henry R

Abstract excerpt

Despite the identification of a growing number of genetic risk loci for substance use traits (SUTs), the impact of these loci on protein abundance and the potential utility of relevant proteins as therapeutic targets are unknown. We conducted a proteome-wide association study (PWAS) in which we integrated human brain proteomes from discovery (Banner; N = 152) and validation (ROSMAP; N = 376) datasets with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35941285
DOI: 10.1038/s41386-022-01406-1
PMCID: PMC9630289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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