Article
Diverse types of genomic evidence converge on alcohol use disorder risk genes.
Journal of medical genetics - 1 Nov 2020
Dai Yulin, Hu Ruifeng, Pei Guangsheng, Zhang Huiping, Zhao Zhongming, Jia Peilin
Abstract excerpt
BACKGROUND: Alcohol use disorder (AUD) is one of the most common forms of substance use disorders with a strong contribution of genetic (50%-60%) and environmental factors. Genome-wide association studies (GWAS) have identified a number of AUD-associated variants, including those in alcohol metabolism genes. These genetic variants may modulate gene expression, making individuals more susceptible to AUD. A...
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