Diverse types of genomic evidence converge on alcohol use disorder risk genes.

doi:10.1136/jmedgenet-2019-106490

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Article

Diverse types of genomic evidence converge on alcohol use disorder risk genes.

Journal of medical genetics - 1 Nov 2020

Dai Yulin, Hu Ruifeng, Pei Guangsheng, Zhang Huiping, Zhao Zhongming, Jia Peilin

Abstract excerpt

BACKGROUND: Alcohol use disorder (AUD) is one of the most common forms of substance use disorders with a strong contribution of genetic (50%-60%) and environmental factors. Genome-wide association studies (GWAS) have identified a number of AUD-associated variants, including those in alcohol metabolism genes. These genetic variants may modulate gene expression, making individuals more susceptible to AUD. A...

Topics

Alcoholism
Brain
Cerebellum
Computational Biology
DNA Methylation
Epigenomics
Female
Frontal Lobe
Gene Expression Regulation
Genetic Association Studies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Human

Genome-Wide Association Study

Genomics

Hippocampus

Humans

Liver

Male

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Identifiers

PMID: 32170004
DOI: 10.1136/jmedgenet-2019-106490
PMCID: PMC7487038

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