Article

Quantification of GC-biased gene conversion in the human genome

2014-10-09

Abstract excerpt

Many lines of evidence indicate GC-biased gene conversion (gBGC) has a major impact on the evolution of mammalian genomes. However, up to now, this process had not been properly quantified. In principle, the strength of gBGC can be measured from the analysis of derived allele frequency spectra. However, this approach is sensitive to a number of confounding factors. In particular, we show by simulations that the in...

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Literature Corpus work: 92cfc250-3eb9-599b-b3ce-cb1c32c47a85
DOI: 10.1101/010173

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