Article
Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences.
eLife - 23 Aug 2018
Pouyet Fanny, Aeschbacher Simon, Thiéry Alexandre, Excoffier Laurent
Abstract excerpt
Disentangling the effect on genomic diversity of natural selection from that of demography is notoriously difficult, but necessary to properly reconstruct the history of species. Here, we use high-quality human genomic data to show that purifying selection at linked sites (i.e. background selection, BGS) and GC-biased gene conversion (gBGC) together affect as much as 95% of the variants of our genome. We find...
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