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Article

Adapting Biased Gene Conversion theory to account for intensive GC-content deterioration in the human genome by novel mutations.

PloS one - 1 Jan 2020

Paudel Rajan, Fedorova Larisa, Fedorov Alexei

Abstract excerpt

We examined seventy million well-characterized human mutations, and their impact on G+C-compositional dynamics, in order to understand the formation and maintenance of major genomic nucleotide sequence patterns. Among novel mutations, those that change a strong (S) base pair G:C/C:G to a weak (W) pair A:T/T:A occur at nearly twice the frequency of the opposite mutations. Such imbalance puts strong downward...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32353016
DOI: 10.1371/journal.pone.0232167
PMCID: PMC7192473

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