Article
1000 human genomes carry widespread signatures of GC biased gene conversion.
BMC genomics - 16 Apr 2018
Dutta Rajib, Saha-Mandal Arnab, Cheng Xi, Qiu Shuhao, Serpen Jasmine, Fedorova Larisa, Fedorov Alexei
Abstract excerpt
BACKGROUND: GC-Biased Gene Conversion (gBGC) is one of the important theories put forward to explain profound long-range non-randomness in nucleotide compositions along mammalian chromosomes. Nucleotide changes due to gBGC are hard to distinguish from regular mutations. Here, we present an algorithm for analysis of millions of known SNPs that detects a subset of so-called "SNP flip-over" events representing...
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