Article
Meiotic recombination favors the spreading of deleterious mutations in human populations.
Human mutation - 1 Feb 2011
Necşulea Anamaria, Popa Alexandra, Cooper David N, Stenson Peter D, Mouchiroud Dominique, Gautier Christian, Duret Laurent
Abstract excerpt
Although mutations that are detrimental to the fitness of organisms are expected to be rapidly purged from populations by natural selection, some disease-causing mutations are present at high frequencies in human populations. Several nonexclusive hypotheses have been proposed to account for this apparent paradox (high new mutation rate, genetic drift, overdominance, or recent changes in selective pressure)....
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