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Article

Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles.

American journal of human genetics - 2 Oct 2014

Lachance Joseph, Tishkoff Sarah A

Abstract excerpt

Gene conversion results in the nonreciprocal transfer of genetic information between two recombining sequences, and there is evidence that this process is biased toward G and C alleles. However, the strength of GC-biased gene conversion (gBGC) in human populations and its effects on hereditary disease have yet to be assessed on a genomic scale. Using high-coverage whole-genome sequences of African...

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PMID: 25279983
DOI: 10.1016/j.ajhg.2014.09.008
PMCID: PMC4185123

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