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Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learning

2026-02-27

Abstract excerpt

<title>Abstract</title> <p>Immunotherapy for colorectal cancer (CRC) currently faces significant dilemmas, but its specific mechanisms remain unclear. T-cell exhaustion (TEX) in the tumor microenvironment has been identified as a pivotal driver of immune evasion and tumor progression. Dissecting its contribution to CRC is essential for the development of rational therapeutic strategies. Here, we integrated scRNA-...

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Literature Corpus work
92ce6f92-4ed8-5743-af41-299a43e16cf0
DOI
10.21203/rs.3.rs-8910521/v1
Open publication

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Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learningDOI 10.21203/rs.3.rs-8910521/v1
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