Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer

9 Aug 2021

Abstract excerpt

Immunotherapy has achieved positive clinical responses in various cancers. However, in advanced colorectal cancer (CRC), immunotherapy is challenging because of the deterioration of T-cell exhaustion, the mechanism of which is still unclear. In this study, we depicted CD8+ T-cell developmental trajectories and characterized the pre-exhausted T cells isolated from CRC patients in the scRNA-seq data set using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34434188
DOI: 10.3389/fimmu.2021.691142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal CancerPMID 34434188Read ↗

Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learningSemantic proximity Read ↗

Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancerSemantic proximity Read ↗

A Multi-Omics Analysis of an Exhausted T Cells’ Molecular Signature in Pan-CancerSemantic proximity Read ↗

Heterogeneity and Differentiation Trajectories of Infiltrating CD8+ T Cells in Lung AdenocarcinomaSemantic proximity Read ↗

PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing TechnologySemantic proximity Read ↗

Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCCSemantic proximity Read ↗

Characterization of Exhausted T Cell Signatures in Pan-Cancer SettingsSemantic proximity Read ↗

Single-Cell Transcriptomic Profiling Reveals T-Cell Functional Shifts in Primary Versus Metastatic Colorectal CancerSemantic proximity Read ↗

The role of CD8+ T-cells in colorectal cancer immunotherapySemantic proximity Read ↗

Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacySemantic proximity Read ↗

High ratio of resident to exhausted CD4+ T cells predicts favorable prognosis and potentially better immunotherapeutic efficacy in hepatocellular carcinomaSemantic proximity Read ↗

Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient’s survival and immunotherapy responsivenessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.