Article

The STING pathway does not contribute to <i>Pink1/parkin</i> phenotypes in <i>Drosophila</i>

2019-10-16

Abstract excerpt

Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson’s disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a central role in mitochondrial homeostasis by signaling the targeted destruction of damaged mitochondria, however, how disrupting this process leads to neuronal death until recently was un...

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Literature Corpus work: 92c5deac-eaf2-5179-bf38-0fe481051483
DOI: 10.1101/806265

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