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Article

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

28 Aug 2018

Abstract excerpt

What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature. https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS–STING pathway that may contribute to Parkinson’s disease.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30154188
DOI: 10.1083/jcb.201808118

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