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Article

The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.

Scientific reports - 14 Feb 2020

Lee Juliette J, Andreazza Simonetta, Whitworth Alexander J

Abstract excerpt

Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms of Parkinson's disease but the precise pathogenic mechanisms are unknown. The PINK1/Parkin pathway has been described to play a central role in mitochondrial homeostasis by signalling the targeted destruction of damaged mitochondria, however, how disrupting this process leads to neuronal death was unclear until...

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Identifiers

PMID: 32060339
DOI: 10.1038/s41598-020-59647-3
PMCID: PMC7021792

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The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.PMID 32060339Read ↗

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