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Article

cGAS-like receptors drive a systemic STING-dependent host response in Drosophila

1 Dec 2024

Abstract excerpt

cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently emerged as an important pathway controlling viral infections in invertebrates. However, its exact contribution at the organismal level remains uncharacterized. Here, we use STING::GFP knockin reporter Drosophila flies to document activation of the pathway in vivo. Four tissues strongly respond to injection of the cyclic dinucleotide 3'2'-...

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PMID: 39688951
DOI: 10.1016/j.celrep.2024.115081

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