Article

Systematic functional dissection of germline noncoding risk variants impacting clonal hematopoiesis

2026-01-23

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is a precursor condition characterized by the expansion of blood cell clones harboring somatic mutations originating in hematopoietic stem cells (HSCs). Since individuals with CHIP face a high risk of developing myeloid malignancies, targeting CHIP clones could provide a viable strategy for leukemia prevention. Despite its clinical significance, the mechanisms...

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Literature Corpus work: 92c542dc-8ec6-5f8a-842e-077fa997923d
DOI: 10.64898/2026.01.21.700897

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