Article

Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer

2020-12-24

Abstract excerpt

<h4>ABSTRACT</h4> Molecular profiling of Pancreatic Ductal Adenocarcinoma (PDA), based on transcriptomic analyses, identifies two main prognostic subtypes (basal-like and classical), but does not allow personalized first-line treatment. To date, tumors have not been profiled based on protein synthesis rates, yet the step of mRNA translation is highly deregulated in both PDA cancer cells and their microenvironment...

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Literature Corpus work: 0262f89b-4a38-5608-b6e6-7a01c9f4346f
DOI: 10.1101/2020.12.23.424227

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