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Article

Exploring molecular genetics of bladder cancer: lessons learned from mouse models.

Disease models & mechanisms - 1 May 2012

Ahmad Imran, Sansom Owen J, Leung Hing Y

Abstract excerpt

Urothelial cell carcinoma (UCC) of the bladder is one of the most common malignancies worldwide, causing considerable morbidity and mortality. It is unusual among the epithelial carcinomas because tumorigenesis can occur by two distinct pathways: low-grade, recurring papillary tumours usually contain oncogenic mutations in FGFR3 or HRAS, whereas high-grade, muscle-invasive tumours with metastatic potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22422829
DOI: 10.1242/dmm.008888
PMCID: PMC3339826

Genes

GEM
FGFR3
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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