Article
Trp53 Mutation in Keratin 5 (Krt5)-Expressing Basal Cells Facilitates the Development of Basal Squamous-Like Invasive Bladder Cancer in the Chemical Carcinogenesis of Mouse Bladder.
The American journal of pathology - 1 Aug 2020
Masuda Norihiko, Murakami Kaoru, Kita Yuki, Hamada Akihiro, Kamada Mayumi, Teramoto Yuki, Sakatani Toru, Matsumoto Keiyu, Sano Takeshi, Saito Ryoichi, Okuno Yasushi, Ogawa Osamu, Kobayashi Takashi
Abstract excerpt
The biological processes of urothelial carcinogenesis are not fully understood, particularly regarding the relationship between specific genetic events, cell of origin, and molecular subtypes of subsequent tumors. N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced mouse bladder cancer is widely accepted as a useful model that recapitulates the pathway of human bladder tumorigenesis from dysplasia to invasive...
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