Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing agreement between different polygenic risk scores in the UK Biobank.

Scientific reports - 27 Jul 2022

Clifton Lei, Collister Jennifer A, Liu Xiaonan, Littlejohns Thomas J, Hunter David J

Abstract excerpt

Polygenic risk scores (PRS) are proposed for use in clinical and research settings for risk stratification. However, there are limited investigations on how different PRS diverge from each other in risk prediction of individuals. We compared two recently published PRS for each of three conditions, breast cancer, hypertension and dementia, to assess the stability of using these algorithms for risk prediction in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multifactorial Inheritance
Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Associations and Epidemiology

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 35896674
DOI: 10.1038/s41598-022-17012-6
PMCID: PMC9329440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing agreement between different polygenic risk scores in the UK Biobank.PMID 35896674Read ↗

Assessing agreement between different polygenic risk scores in the UK BiobankSemantic proximity Read ↗

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for EpidemiologistsSemantic proximity Read ↗

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives.Semantic proximity Read ↗

Benchmarking Polygenic Risk Score Model Assumptions: towards more accurate risk assessmentSemantic proximity Read ↗

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification.Semantic proximity Read ↗

Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB.Semantic proximity Read ↗

A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release.Semantic proximity Read ↗

Evaluation of polygenic risk scores for predicting breast and prostate cancer risk.Semantic proximity Read ↗

Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic DatasetsSemantic proximity Read ↗

Improving reporting standards for polygenic scores in risk prediction studiesSemantic proximity Read ↗

Polygenic scores for UK Biobank scale dataSemantic proximity Read ↗

Polygenic risk scores and breast cancer risk prediction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.