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Article

Addressing overfitting bias due to sample overlap in polygenic risk scoring.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2025

Jeong Seokho, Shivakumar Manu, Jung Sang-Hyuk, Won Hong-Hee, Nho Kwangsik, Huang Heng, Davatzikos Christos, Saykin Andrew J, Thompson Paul M, Shen Li, Kim Young Jin, Kim Bong-Jo, Lee Seunggeun, Kim Dokyoon

Abstract excerpt

INTRODUCTION: Numerous studies on Alzheimer's disease polygenic risk scores (PRSs) overlook sample overlap between International Genomics of Alzheimer's Project (IGAP) and target datasets like Alzheimer's Disease Neuroimaging Initiative (ADNI). METHODS: To address this, we developed overlap-adjusted PRS (OA PRS) and tested it on simulated data to assess biases from different scenarios by varying training,...

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PMID: 40189831
DOI: 10.1002/alz.70109
PMCID: PMC11972974

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