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pH-dependent beta-lactam resistance in <i>Klebsiella pneumoniae</i> is mediated by paralogous class B PBPs and the class A PBP, PBP1b

2025-03-12

Abstract excerpt

Klebsiella pneumoniae is a leading cause of global deaths due to antibiotic resistance. Of particular concern is the rapid expansion of resistance to beta-lactam antibiotics within K. pneumoniae lineages. The environmental factors that influence pathogen physiology and, subsequently, antibiotic resistance remain poorly understood. Here we demonstrate that physiologically-relevant reductions in pH increased K. pn...

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Literature Corpus work
26132088-c0be-5bf2-b4c7-f6b275d133f3
DOI
10.1101/2025.03.12.642896
Open publication

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pH-dependent beta-lactam resistance in <i>Klebsiella pneumoniae</i> is mediated by paralogous class B PBPs and the class A PBP, PBP1bDOI 10.1101/2025.03.12.642896
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