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PhoPQ-mediated lipopolysaccharide modification regulates intrinsic resistance to tetracycline and glycylcycline antibiotics in <i>Escherichia coli</i>

2024-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Tetracyclines and glycylcycline are among the last-resort antibiotics used to combat infections caused by multidrug-resistant Gram-negative pathogens. Despite the clinical importance of these antibiotics, their mechanisms of resistance remain unclear. In this study, we elucidated a novel mechanism of resistance to tetracycline and glycylcycline antibiotics via lipopolysaccharide (LPS) modificati...

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Literature Corpus work
142e3f6e-0f2f-51ba-be69-17e1edf07b13
DOI
10.1101/2024.07.01.601565
Open publication

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PhoPQ-mediated lipopolysaccharide modification regulates intrinsic resistance to tetracycline and glycylcycline antibiotics in <i>Escherichia coli</i>DOI 10.1101/2024.07.01.601565
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