Article

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity

2025-12-17

Abstract excerpt

<h4>SUMMARY</h4> Alkylation chemotherapy is commonly used against tumors such as glioblastoma, yet resistance often develops through downregulation of mismatch repair (MMR). Previous work has established that loss of MMR prevents the excision of the thymine-containing strand across O 6 meG-T mismatches. Thus, MMR dysfunction is advantageous because it prevents a vicious cycle of attempted repair that leads to ce...

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Literature Corpus work: 927f3df4-dbf9-5dbb-bba5-1ca84703ad3d
DOI: 10.64898/2025.12.15.694403

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