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The dual role of DNA repair protein MGMT in cancer prevention and treatment

13 Jan 2023

Abstract excerpt

Alkylating agents are genotoxic chemicals that can induce and treat various types of cancer. This occurs through covalent bonding with cellular macromolecules, in particular DNA, leading to the loss of functional integrity under the persistence of modifications upon replication. O 6 -alkylguanine ( O 6 -AlkylG) adducts are proposed to be the most potent DNA lesions induced by alkylating agents. If not repaired...

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PMID: 36680944
DOI: 10.1016/j.dnarep.2023.103449

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