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Article

Clinical Relevance of <i>MGMT</i> in the Treatment of Cancer

1 May 2002

Abstract excerpt

Anumber of DNA-damaging chemotherapeutic agents attack the O(6) position on guanine, forming the most potent cytotoxic DNA adducts known. The DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), encoded by the gene MGMT, repairs alkylation at this site and is responsible for protecting both tumor and normal cells from these agents. Cells and tissues vary greatly in AGT expression, not only between...

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Identifiers

PMID: 11981013
DOI: 10.1200/jco.2002.06.110

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