Article

Regulatory architecture of the RCA gene cluster captures an intragenic TAD boundary, CTCF-mediated chromatin looping and a long-range intergenic enhancer

2020-02-17

Abstract excerpt

<h4>ABSTRACT</h4> The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 ( CR2 ), are well-established susceptibility genes in complex autoimmune diseases. Altered expression of RCA genes has been demonstrated at both the functional and genetic level, but the mechanisms underly...

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Literature Corpus work: 926c3659-7baa-58b6-a5d9-eab6f630cf36
DOI: 10.1101/2020.02.16.941070

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