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Article

Epigenetic regulation of complement C1Q gene expression

3 Dec 2024

Abstract excerpt

Human C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA, C1QB, and C1QC genes located on chromosome 1. C1q, unlike most complement components, has extrahepatic expression by a range of cells including macrophages, monocytes and immature dendritic cells....

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PMID: 39697348
DOI: 10.3389/fimmu.2024.1498097

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