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Article

High-throughput complement component 4 genomic sequence analysis with C4Investigator.

HLA - 1 Jan 2024

Marin Wesley M, Augusto Danillo G, Wade Kristen J, Hollenbach Jill A

Abstract excerpt

The complement component 4 gene loci, composed of the C4A and C4B genes and located on chromosome 6, encodes for complement component 4 (C4) proteins, a key intermediate in the classical and lectin pathways of the complement system. The complement system is an important modulator of immune system activity and is also involved in the clearance of immune complexes and cellular debris. C4A and C4B gene loci exhibit...

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PMID: 37899688
DOI: 10.1111/tan.15273
PMCID: PMC11099535

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