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Article

Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.

Human molecular genetics - 22 Jun 2022

Dahlqvist Johanna, Fulco Charles P, Ray John P, Liechti Thomas, de Boer Carl G, Lieb David J, Eisenhaure Thomas M, Engreitz Jesse M, Roederer Mario, Hacohen Nir

Abstract excerpt

BACKGROUND: FCGR2A binds antibody-antigen complexes to regulate the abundance of circulating and deposited complexes along with downstream immune and autoimmune responses. Although the abundance of FCRG2A may be critical in immune-mediated diseases, little is known about whether its surface expression is regulated through cis genomic elements and non-coding variants. In the current study, we aimed to characterize...

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Identifiers

PMID: 34970970
DOI: 10.1093/hmg/ddab372
PMCID: PMC9239749

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