Article

NLRP1 and NLRP3 trigger inflammasome activation in CD8+ T cells of ART-treated HIV patients and contribute differently to their chronic activation

2024-01-03

Abstract excerpt

<title>Abstract</title> <p>Chronic HIV infection leads to persistent immune activation and inflammation, which can impair the function of CD8+ T cells and their immune competence against infections and tumours. Independently from anti-retroviral treatment, in HIV patients, circulating leukocytes exhibit heightened expression of exhaustion markers and inflammasome-related genes. This study delves into the dysregul...

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Literature Corpus work: 92621ece-e7d6-56ed-b3f1-e41423a7a885
DOI: 10.21203/rs.3.rs-3715397/v1

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NLRP1 and NLRP3 trigger inflammasome activation in CD8+ T cells of ART-treated HIV patients and contribute differently to their chronic activationDOI 10.21203/rs.3.rs-3715397/v1Read

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