Article

The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4 <sup>+</sup> T cell depletion, viral load and total HIV-1 DNA in HIV-1 infected humanized mice

2022-09-04

Abstract excerpt

<h4>Background</h4> HIV-1 infection results in the activation of inflammasome involving NLRP3, IFI16, caspase-1 and release of IL-1 β and IL-18. Early inflammasome activation may facilitate viral spread and establishment of the viral reservoir. We evaluated the effect of the caspase-1 inhibitor VX-765 on virological and immunological parameters after HIV-1 infection in humanized mice. <h4>Methods</h4> NSG mice w...

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Literature Corpus work: fd34b11c-3caa-5f8a-84d9-58c331164e35
DOI: 10.1101/2022.09.01.502964

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