Article

CARD8 inflammasome mediates pyroptosis of HIV-1-infected cells by sensing viral protease activity

2020-09-25

Abstract excerpt

HIV-1 has high mutation rates and exists as mutant swarms in the host. Rapid evolution of HIV-1 allows the virus to outpace host immune system, leading to viral persistence. Novel approaches to target immutable components are needed to clear HIV-1 infection. Here we report a pattern-recognition receptor CARD8 that senses enzymatic activity of the HIV-1 protease, which is indispensable for the virus. All subtypes o...

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Literature Corpus work: 47bce604-bdeb-5221-a1b0-38b4f5d589bc
DOI: 10.1101/2020.09.25.308734

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