CCR2 ⁺ neutrophils exhibit a proinflammatory phenotype and promote plaque destabilization

Abstract excerpt

<h4>Background</h4> Atherosclerotic plaque destabilization is promoted by inflammatory cell recruitment, tissue cell death and mechanical weakening. Neutrophils are key instigators of vascular tissue injury and perpetuation of inflammation, and targeting their actions is a viable therapeutic opportunity. We here identify a distinct subset of activated neutrophils within atherosclerotic lesions that express the ch...

Topics

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• Chemokine CCL2
• Extracellular Traps
• Mice, Knockout, ApoE
• Neutrophil Infiltration
• Neutrophils
• Plaque, Atherosclerotic
• Receptors, CCR2
• Rupture, Spontaneous

Identifiers and source

Literature Corpus work

924a208c-8459-5f16-badf-2c46c22768b7

DOI

10.1101/2025.08.06.669018