Article

CCL2/CCR2 inhibition in atherosclerosis: a meta-analysis of preclinical studies

2021-04-18

Abstract excerpt

<h4>Rationale</h4> The CC-chemokine ligand-2 (CCL2)/ CC-chemokine receptor-2 (CCR2) axis governs monocyte recruitment to atherosclerotic lesions. Coherent evidence from experimental studies employing genetic deletion of CCL2 or CCR2 and human epidemiological studies support a causal involvement of the CCL2/CCR2 axis in atherosclerosis. Still, preclinical studies testing pharmacological inhibition of CCL2 or CCR2...

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Literature Corpus work: 950b24a0-58f0-5059-a74a-e5f5c91f3f1f
DOI: 10.1101/2021.04.16.439554

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