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Article

CCR2+ Neutrophils Exhibit a Proinflammatory Phenotype and Contribute to Plaque Vulnerability.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2026

Farjia Merieme, Pan Chang, Braster Quinte, Lemnitzer Patricia, Sachs Nadja, Vöcking Lina Marie, Chevre Raphael, Malamud Mariano, Schulz Christian, Maegdefessel Lars, Soehnlein Oliver, Silvestre-Roig Carlos

Abstract excerpt

BACKGROUND: Atherosclerotic plaque destabilization is promoted by inflammatory cell recruitment, tissue cell death, and mechanical weakening. Neutrophils drive vascular tissue injury and perpetuate inflammation and represent a viable therapeutic opportunity. Here, we identify a distinct subset of activated neutrophils within atherosclerotic lesions that express the chemokine receptor CCR2 (C-C chemokine receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42131921
DOI: 10.1161/ATVBAHA.126.324654

Genes

CCR2
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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