Article

Cellular Immune Responses Induced by Subretinal AAV Gene Transfer can be Restrained by the Subretinal Associated Immune Inhibition Mechanism

2023-01-02

Abstract excerpt

For more than a decade, AAV-mediated gene transfer has been tested successfully in clinical trials to treat inherited retinal diseases. Despite the eye’s immune-privileged status and the use of corticoids as an adjunct treatment, some patients display inflammatory events which led us to question the immune consequences of a subretinal AAV administration. We first characterized anti-transgene immune responses induc...

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Literature Corpus work: 9338f942-0b02-5727-a0fe-8249e1979107
DOI: 10.1101/2022.12.30.522324

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